Matched T cell repertoire analysis of peripheral blood and tumor-infiltrating lymphocytes (TILs) in early stage breast cancer (ESBC) patients (pts) treated with pre-operative cryoablation (cryo) and/or Ipilimumab (Ipi)

Journal for ImmunoTherapy of Cancer（2014）

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摘要

Meeting abstracts Cryo plus anti-CTLA-4 therapy induces antigen-specific clonal T cell expansion, enhanced survival, and long-term anti-tumor immunity in mice [[1][1]]. We recently demonstrated that pre-operative cryo and/or anti-CTLA-4 therapy with Ipi is well tolerated and clinically feasible in

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关键词

Peripheral Blood Mononuclear Cell, Cell Clone, Ipilimumab, Deep Sequencing, Early Stage Breast Cancer

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