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半胱氨酸蛋白酶激动剂、X连锁凋亡抑制蛋白、半胱氨酸天冬氨酸蛋白酶3在鼻腔鼻窦鳞状细胞癌中的表达

杨莉晖,单春光,黄红梅,许秋荣,赵颖,贾文学,王利军,苏宪

Chinese Archives of Otolaryngology-Head and Neck Surgery（2012）

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Abstract
现代肿瘤学认为肿瘤的发病与细胞凋亡数量的减少密切相关,第二个线粒体衍生的半胱氨酸蛋白酶激动剂(second mitochondria-derived activator of caspase,Smac)、X连锁凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)、半胱氨酸天冬氨酸蛋白酶3(cysteine containing aspartate specific protease,caspase-3)在细胞凋亡过程中起着重要的调控及效应作用.本研究采用免疫组化方法观察三者在鼻腔鼻窦鳞状细胞癌(nasal squamous cell carcinoma,NSCC)及不同病理分期中的表达情况.
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