The effect of extracts of Irvingia gabonensis (IGOB131) and Dichrostachys glomerata (Dyglomera™) on body weight and lipid parameters of healthy overweight participants

Background: Previous work reported the benefits of extracts of 2 Cameroonian spices - Irvingia gabonensis and Dichrostachys glomerata- on obese people with metabolic syndrome. Considering the physio-metabolic changes that accompany obesity, the present study investigates the effects of these extracts on healthy overweight participants over an 8-week test period. Methods: The study was an 8 week randomized double-blind, placebo controlled design involving 48 overweight (BMI 26 - 30) participants (27 females and 19 males), divided into 3 groups - placebo, 300 mg I. gabonensis extract (IGOB131), or 300 mg D. glomerata extract (Dyglomera (TM)). Capsules containing the placebo or the test formulations were administered once daily before the main meal of the day. No major dietary changes or changes in physical activity were demonstrated during the study. Weight and blood lipid parameters were measured at baseline, and at the 4 and 8 weeks interval. Results: Compared to the placebo group, there were significant (p<0.05) reductions in weight of participants in both test groups over the 8 week period. However, these significant changes were not observed in the initial 4 weeks, even though the lipid parameters in the test groups changed significantly (p<0.05). Conclusion: The extracts of Irvingia gabonensis and Dichrostachys glomerata, at a dose of 300 mg per day, were effective in reducing weight and positively modifying lipid parameters in healthy overweight participants.