Characterization of Risk Factors for Modeling of Type 2 Diabetes Mellitus Induced by a High-Fat Diet in C57BL/6 Mice

N. A. Borozdina, E. R. Shaikhutdinova, G. A. Slashcheva, N. A. Goryacheva, A. V. Zamyatina, E. S. Sadovnikova,I. A. Pakhomova, V. M. Pavlov, N. A. Perepechenova, M. S. Severyukhina, A. Yu. Fedotova, D. V. Popkova,I. N. Gladkikh,E. V. Leichenko,I. A. Dyachenko

Bûlletenʹ èksperimentalʹnoj biologii i mediciny（2024）

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Abstract

Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were kept on a high-fat diet for 21 weeks. The animals showed a significant increase in fasting and postprandial glucose levels and body weight, the development of insulin resistance, and by week 18, an increase in the serum TNFα level. Metformin therapy at a dose of 250 mg/kg was effective against the background of disturbances in carbohydrate metabolism: animals showed a significant decrease in insulin resistance and TNFα level.

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Key words

diabetes mellitus type 2,high-fat diet,insulin resistance,metformin,C57BL/6 mice

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