室温下铜催化制备含羰基或酯基的喹唑啉-4(3 H )-亚基类衍生物

At room temperature, a new simple and efficient copper-catalyzed method for the synthesis of quinazolin-4(3H)-ylidene derivatives containing carbonyl and ester group was developed. The targets were prepared using methyl 3-(2-bromophenyl)-3-oxopropanoate analogues and amidine hydrochlorides as the initial materials, cuprous iodide as catalyst, and potassium phosphate as base at the ligand-free condition. Their structures were confirmed by H-1 NMR, C-13 NMR and BRMS.