Aortic Lumen Diameter And Blood Pressure Changes Dynamics After Replacing Aorta Abdominalis With Prosthesis

The aim of this study was to find out the biointegration of innovative vascular prosthesis, made in Riga Technical University (RTU), in dog's abdominal aorta. The research is being performed in Veterinary Medicine Faculty of Latvia University of Agriculture since July 19. 2011. We used 9 female gender, 1-3 years old Beagle dogs in this study. The research is approved by the Latvian Republic Food and Veterinary Service. The study is carried out in the frame of European Social Fund co-financed project 'Establishment of interdisciplinary research groups for a new functional properties of smart textiles development and integrating in innovative products' (ESF No. 2009/0198/1DP/1.1.1.2.0./09/APIA/VIAA/148). 5-8 mm in diameter, 8 mm - 18 mm in length RTU produced aortic grafts were implanted retroperitoneal in dogs. Before the surgery the diameter of abdominal aorta was measured in cross sections, afterwards - cranial and caudal from the prosthesis, as well cross-section diameter of vascular graft was measured. Blood pressure was measured before the surgery and after the procedure on regular basis. Results are the following: there are no significant differences in aortic and graft diameter before and 1-2 months after the operation, there are no significant differences in systolic and diastolic blood pressure before and four months after the surgery at significance level alpha = 0.05. The study shows that the innovative aortic prostheses don't change in diameter, and surgery like abdominal aorta transplantation doesn't cause significant variations in blood pressure. The study is being continued to find out later reactions to synthetic vascular graft.