PROMOTION OF CHEMICAL CARCINOGENESIS AND P53 EXPRESSION BY REDUCTION OF SUPEROXIDE DISMUTASE ACTIVITY IN THE LUNG OF RAT IN VIVO *
Chinese Journal of Cancer Research(2013)
摘要
In the present experiment, an inhibitor of superoxide dismutase (SOD), diethyldithiocarbamate (DETC), was used to decrease
SOD activity for the observation of the relation between SOD activity and carcinogenesis and the expression of P53 proteinin vivo. 144 Wistar rats were used for the present study. The results showed that the SOD activity reduction by DETC resulted markedly
in the promotion of the carcinogenesis and the expression of P53 protein in the lung tissues, but the increase of SOD activity
by the addition of plus SOD inhibited the pathological changes significantly. The frequency of the pathological lesions and
positive P53 expression are 36/42 and 8/42 in the animals without DETC and SOD; 16/52 and 4/52 in the animals with SOD and
46/50 and 26/50 in the animals with DETC respectively. The results reported in this paper suggest that: (1) the decrease of
SOD activity enhanced the carcinogenesis induced by chemical carcinogen; (2) P53 gene may be associated with the process of
tumorigenesis; and (3) at the same time the abnormal expression of P53 protein may be associated with the transition from
premalignant lesions to carcinoma.
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关键词
Superoxide dismutase,Carcinogenesis,Gene expression,P53,Lung,rat
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