Exploring Default Mode Connectivity Using Region of Interest Analysis in Children with Attention Deficit and Hyperactivity Disorder

In this preliminary study, functional connectivities among brain default mode network (DMN) regions were aimed to investigate using resting-state functional magnetic resonance imaging. 13 children diagnosed with ADHD whose ages are between 9 and 16 and 13 healthy controls in the same ages were studied using ROI-to-ROI analysis method. Major Default Mode Networks(DMN) investigated were medial prefrontal cortex (MPFC), Posterior cingulate cortex, right parietal cingulate lobe (right IPL) and left parietal cingulate lobe (left IPL). The group level comparison was performed on functional MR images after spatial and temporal preprocessing. Functional activities of control and DEHB groups were examined and meaningful results were obtained associating with anatomical regions. In the ADHD group, increased connectivity between right inferior parietal lobe and left inferior parietal lobe and decreased connectivity between other DMN regions were obtained significantly compared to the control group.