Antibacterial activity of novel 2-(substituted sulfonamido) benzoic acid derivatives

Sulfonamides were the first chemotherapeutic agents to be used in human, systemically for the treatment of bacterial infection. Though, varieties of sulfonamides are currently available, bacteria have developed resistance to them. This prompted to search for the novel sulfonamide based antibacterials. Novel 2-(substituted sulfonamido) benzoic acid derivatives were tested for their antibacterial activity against 19 Gram −ve and 2 Gram +ve pathogenic bacteria and MIC values were determined by agar dilution method. The tested compounds showed moderate to good antibacterial activity against tested bacteria. Compounds, A5, A12, A15, A18 and A19 were showed moderate antibacterial activity against atypical Escherichia coli. Compounds, A13 and A14 showed good antibacterial activity (MIC = 183.81 μg/ml) against Plesiomonas shigelloides and atypical E. coli, respectively. This study concludes that further structural optimization of 2-(substituted sulfonamido) benzoic acid series would bring more potent useful agents to treat infections caused by range of bacteria.