Adjuvant Bisphosphonates And Breast Cancer Survival
ANNUAL REVIEW OF MEDICINE, VOL 67(2016)
Abstract
Randomized trials have studied bisphosphonates in the adjuvant setting of early breast cancer to investigate their ability to prevent treatment-induced bone loss. Trial results have also suggested their potential to prevent disease recurrence and metastases. These trials are summarized in this review. A recent patient-level meta-analysis by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) finds convincing evidence that adjuvant antiresorptive treatments provide persistent benefits to breast cancer patients in low-estrogen situations and should be considered an important part of the treatment algorithm.
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Key words
antitumor effect,adjuvant therapy,bone loss,postmenopause,dormant tumor cells
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