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Activation of the COX2-PGE 2 axis by immune effector cells results in the self-limiting nature of type-1 immunity in cancer tissues

Jeffrey L Wong,Natasa Obermajer,Ravikumar Muthuswamy,Robert P Edwards,Kunle Odunsi,David L Bartlett,Pawel Kalinski

Journal for ImmunoTherapy of Cancer（2014）

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Abstract
Meeting abstracts Type-1 immune responses, mediated by IFNγ and TNFα-producing CTLs, Th1, and NK cells, are essential for effective anti-tumor immunity. Despite recent advances in the induction and stabilization of these responses by cancer immunotherapies, the clinical success of these
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Key words
Nitric Oxide, Cancer Immunotherapy, Immune Effector Cell, Intrinsic Mechanism, PGE2 Synthesis
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