Bioinspired Anti-Biofilm Surfaces Based On Topographical Cues

Adhesion of bacteria to surfaces is the starting point for formation of biofilms, which tend to be significantly less responsive to antibiotics and antimicrobial stressors, compared with planktonic bacteria. The physicochemical properties of natural anti-biofilm surfaces are being actively studied to develop bioinspired anti-biofilm strategies. It has been shown that –majority of natural anti-biofilm surfaces have well organized micro/nanoscale surfaces features [1]. The difficulties associated with the manufacturing of well-defined and controlled nano-textured surfaces and complexity of the behaviour of microorganisms interacting with engineered surfaces has limited rigorous quantitative study of the state of adhesion of fouling microorganisms to engineered surfaces. The work presented here aims to advance the current understanding of cell-textured surface interaction with the ultimate goal of developing an anti-biofilm design framework based on topographical cues.