Tumor vascular normalization as a strategy to potentiate effectiveness of therapeutic vaccines

Benedetto Farsaci,Renee N Donahue,Michael A Coplin,Italia Grenga,Lauren Lepone,Alfredo A Molinolo,James W Hodge

Journal for ImmunoTherapy of Cancer（2014）

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摘要

Meeting abstracts The effectiveness of cancer immunotherapy can be compromised when immune cells cannot penetrate the tumor. We hypothesize that combining an antiangiogenic tyrosine kinase inhibitor (TKI) with a cancer vaccine can increase antitumor response by targeting 3 elements of the tumor

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关键词

Sorafenib,Tight Junction,Sunitinib,Tyrosine Kinase Inhibitor,Tumor Vasculature

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