. Transcriptional Quiescence Of Hematopoietic Stem Cells

Haematopoietic stem cells (HSC) have the exceptional capacity to undergo continuous selfrenewal and differentiation into multiple lineages, which is essential for haematopoietic homeostasis and response to injury. To achieve this life long function, these cells have to be protected from cytotoxic and genetic damage. On the other hand, rapid activation of haematopoietic stem cell proliferation in response to stimuli must be ensured. While cellular quiescence is thought to be the key mechanism underlying this paradoxical nature of HSC, the molecular basis of induction and maintenance of quiescence remains unresolved.