Determinação direta do aciclovir em leite materno pelo uso de um sensor eletroquimico

Acyclovir is an important antiviral drug of positive action on survival of immunosuppressed individuals. Nevertheless, there is a need for further comprehension among toxicological phenomena, which become even more relevant when related to lactation. Sensors development is an analytical proposal very attractive, from the viewpoint of direct analysis about drugs in complex samples, such as breast milk. In this work, it was developed an electrochemical sensor based on carbon paste, once appropriate conditions were in place to enhance signal resolution and analytical quality. In the determination of acyclovir into breast milk samples, collected and stored in natura, it was verified that sample volumes greater than 25 μL can interfere with the analytical signal. Acyclovir presented electrochemical activity with peak of oxidation quite defined in 0,705 V vs (Ag/AgCl. The method employed presented suitable sensitivity, accuracy and precision for analysis of acyclovir in breast milk samples. Index Terms - voltammetry, acyclovir, breastmilk.