LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation
Atherosclerosis(2016)
Abstract
•Some LMNA mutations and HIV antiretrovirals induce vascular muscle cell dysfunction.•Cell alterations include senescence and osteogenic transdifferentiation/calcification.•Decreased expression of ZMPSTE24, a prelamin A maturation enzyme, is a leading factor.•This may contribute to LMNA or HIV-linked premature atherosclerosis and calcification.•Decreased ZMPSTE24 could be involved in pathological and physiological vascular aging.
MoreTranslated text
Key words
Vascular smooth muscle cells,ZMPSTE24,Prelamin A,Senescence,Osteogenic transdifferentiation,Atherosclerosis
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined