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Effect of Ribocitrin on Glucan Synthesizing Enzymes of Streptococcus mutans E49

Agricultural and Biological Chemistry(2014)

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Abstract
Enzymes participating in glucan synthesis by Streptococcus mutans E49 were separated into two fractions with distinctly different activities by chromatography on DEAE Bio-Gel A. The insoluble glucan (IG) was revealed to be formed by the coupling reaction of these two enzymes, dextransucrase (SGE), which synthesizes soluble glucan from sucrose, and a glucan insolubilizing enzyme (IGE), which forms IG from soluble glucan.Ribocitrin was found to inhibit IG synthesis by inhibiting SGE.
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glucan synthesizing enzymes ofstreptococcus,ribocitrin
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