Effect of Ribocitrin on Glucan Synthesizing Enzymes of Streptococcus mutans E49
Agricultural and Biological Chemistry(2014)
Abstract
Enzymes participating in glucan synthesis by Streptococcus mutans E49 were separated into two fractions with distinctly different activities by chromatography on DEAE Bio-Gel A. The insoluble glucan (IG) was revealed to be formed by the coupling reaction of these two enzymes, dextransucrase (SGE), which synthesizes soluble glucan from sucrose, and a glucan insolubilizing enzyme (IGE), which forms IG from soluble glucan.Ribocitrin was found to inhibit IG synthesis by inhibiting SGE.
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Key words
glucan synthesizing enzymes ofstreptococcus,ribocitrin
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