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New-Generation Sequencing (Ngs) In Hematologic Oncology Laboratories

Alice Marceaurenaut,Aline Renneville,Olivier Nibourel, Olivia Jardinmathe, Christophe Demay,Celine Villenet,Sandrine Geffroy,Nathalie Helevaut,Sabine Quief,Chadi Saad,Nathalie Grardel,Aurelie Caillault,Nicolas Duployez,Thomas D Boyer,Christophe Roumier,Frederic Lepretre,Meyling Cheok,Nicole Porchet,Martin Figeac, Claude Preudhomme

HEMATOLOGIE（2013）

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Abstract
New-generation sequencing (NGS) is a true technological leap forward. Although the first applications have mainly focused on whole-genome sequencing intended to identify new gene mutations, it is appearing today in hospital laboratories as an approach to targeted resequencing. Hospital applications in hematologic oncology are currently being transferred to this technology, with numerous advantages but also some constraints. The objective of this review to take an inventory of NGS in our discipline at the beginning of 2013.
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Key words
NGS, resequencing, leukemia, mutation, bioinformatics
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