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CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination

Janet E Holley,Edwin Bremer,Alexandra C Kendall,Marco De Bruyn,Wijnand Helfrich,Joanna M Tarr,J Newcombe,N J Gutowski,Paul Eggleton

Multiple Sclerosis and Related Disorders（2014）

Cited 48|Views18
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Abstract
•We detected CD20+T-cells in the blood and brains of MS patients.•Some CD20+T cells in the brains were positive for IL-17.•Blood CD20+ and CD20- T cells both produced INF-γ and IL-4.•Rituximab alone is a poor therapeutic at eliminating T-cells.•An engineered scFvRit:sFasL molecule specifically kills CD20+T-cells.
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Key words
Biologics,Chronic lesions,Human tissue,Interleukin-17,T-cells
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