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Topical cathelicidin (LL-37) an innate immune peptide induces acute olfactory epithelium inflammation in a mouse model.

Jeremiah A Alt,Xuan Qin,Abigail Pulsipher,Quinn Orb,Richard R Orlandi,Jianxing Zhang,Austin Schults,Wanjian Jia,Angela P Presson,Glenn D Prestwich,Siam Oottamasathien

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY（2015）

Cited 11|Views11
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Abstract
LL-37 has dramatic inflammatory effects in the OE mucosa that is dose-dependent. The observed inflammatory changes in the olfactory mucosa were associated with the infiltration of both neutrophils and mast cells. Our biologic model represents a new model to further investigate the role of LL-37 in OE inflammation.
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Key words
cathelicidin,chronic disease,innate immunity,rhinosinusitis,sinusitis
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