Sat1 And Glioblastoma Multiforme: Disarming The Resistance
MOLECULAR & CELLULAR ONCOLOGY（2015）
Abstract
Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
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Key words
BRCA1,glioblastoma,histone acetylation,SAT1,radiation resistance
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