Clinical Effects of Glucosamine Hydrochloride Diet for Dry Skin.

A placebo-control double-blind study of long-term intake of glucosamine hydrochloride (1 500 mg/day for 6 weeks) was conducted in 32 women who usually tend to have dry and rough skin. The following findings were obtained: (1) Examination by dermatologists indicated that glucosamine hydrochloride significantly improved dryness of the skin, easiness to apply make-up, and exfoliation. (2) Determination of the moisture content in the skin revealed that glucosamine hydrochloride increased the moisture content in the skin. (3) Microscopic skin surface analysis showed that glucosamine hydrochloride improved smoothness and scaliness of the skin. These findings suggested that long-term intake of glucosamine hydrochloride is effective in improving moisture content and smoothness of the skin.