Proteomic profiling of hyperplasia/atypia and adenoma-induced by NNK in mouse lung identified multiple proteins as potential biomarkers for early detection

Arunangshu Das,James D Bortner,Cesar Aliaga,Timothy K Cooper,Anne Stanley,Bruce A Stanley,Chandra P Belani,Karam Elbayoumy

EuPA Open Proteomics（2015）

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摘要

•Multiple proteins were modulated during early stages of lung tumorigenesis.•Cbr2, Anx A, Selenbp1, Hmgb1, Hsp90b1 were modified during hyperplasia/atypia/adenoma.•These proteins are potential biomarkers for early stages of lung tumorigenesis.

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关键词

NNK4,p-XSC,iTRAQ,SCLC,NSCLC,MS,IARC,ABI,TEAB,TCEP,LC,SCX,MALDI,CHCA,MS/MS,FDR,PSPEP,MIAPE,EF,GO,PANTHER,IPA,ECL,Cbr,Hmgb1,Selenbp1,Hsp90b1,RAGE

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