Synthesis and in Vitro Antimicrobial Activity of some New 3, 5 di-substituted pyrazoline derivatives

Pyrazoline derivatives are found to be chemotherapeutically active and they are found to possess anti-inflammatory, anti-bacterial, anti-viral and analgesic activities. The objective of the dissertation work is to synthesize and characterization of 3,5-di-substituted pyrazolines and also to study their anti-bacterial activities.The method followed to synthesize 3,5 di-substituted pyrazolines are as follows: The results have shown that the 3,5 di-substituted pyrazoline derivatives are found to be effective anti-bacterial agents. The synthesized compounds were elucidated by spectral data. By analysis of IR, NMR and MASS spectral data the compounds reveals the successful information of 3,5-di-substituted pyrazolines and also about different aromatic groups at position 3 and 5. The synthesized compounds were screened for their anti-bacterial activities by using standard as ampicilin and are found to be effective chemotherapeutic agent. The synthesis of pyrazolines by the described methods resulted in the products with good yield.