Tumor immunologic heterogeneity influences response to radiation and combination immunotherapy

Todd Aguilera,Marjan Rafat,Mihalis Kariolis,Rie von Eyben,Edward Graves,Amato Giaccia

Journal for ImmunoTherapy of Cancer（2015）

引用 4|浏览7

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摘要

Meeting abstracts Clinical trials of CTLA-4 and PD-1/PD-L1 antibodies (Ab) have shown responses limited to 10-30% of patients. Increasing evidence suggests radiation (RT) can enhance responses to checkpoint therapies. However, understanding of tumor-derived factors that influence response is

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关键词

Tumor Microenvironment, Macrophage Infiltration, Myeloid Derive Suppressor Cell, Clonogenic Survival, Tumor Clone

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