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Counteracting breast-cancer induced immune suppression by reactivating lymph node-resident conventional dendritic cells (LNR-cDC)

Rieneke van de Ven,Kim van Pul,Shaghayegh Aliabadi,Petrousjka van den Tol, Lisette A te Velde,Emiel JTh Rutgers,Ronald JCLM Vuylsteke,Hein BAC Stockmann,Christopher Dubay,Chris Harrington,Bernard A Fox,Tanja D de Gruijl

Journal for ImmunoTherapy of Cancer（2015）

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Abstract
Meeting abstracts Breast cancer (BrC)-derived factors inhibit proper development and activation of dendritic cells (DC), which in turn promote the expansion of regulatory T cells (Tregs), thus contributing to tumor progression and spread. In two separate BrC sentinel lymph node (SLN) cohorts, one
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Key words
Dendritic Cell, Sentinel Lymph Node, Immune Suppression, Treg Frequency, Efficient Antigen
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