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Treatment with the IDO inhibitor INCB024360 increased lysis of human tumor cell targets by peptide-specific CTL

Caroline Jochems,Anna Kwilas,Young-Seung Kim,Martin W Brechbiel,Massimo Fantini,Simon Metenou,Romaine I Fernando,Peter S Kim,Sofia Gameiro,James Hodge,Robert Newton,Jeffrey Schlom,Kwong Y Tsang

Journal for ImmunoTherapy of Cancer（2015）

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Abstract
Meeting abstracts We have investigated the in vitro effects of INCB024360 on dendritic cell maturation and activation of antigen-specific T cells. INCB024360 is a novel inhibitor of indoleamine-2, 3-dioxygenase (IDO), and is currently in several ongoing clinical trials. INCB024360 effectively
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Pancreatic Carcinoma,Prostate Cancer Patient,Human Breast Cancer Cell Line,Kynurenine,Dendritic Cell Maturation
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