脑震荡急性期患者功能磁共振低频振幅变化意义初探The Changes of Amplitude of Low-Frequency Fluctuation in the Acute Phase Patients with Concussion

目的：探讨伴有认知功能改变的脑震荡急性期患者功能磁共振低频振幅(ALFF)变化与其临床症状之间的关系。方法：采用静息态血氧水平依赖功能磁共振成像(BOLD-fMRI)及其低频振幅(ALFF)计算法，对急性期伴有认知功能改变的脑震荡患者在静息状态下获得相关资料进行分析。研究组为脑震荡成年患者10人；对照组为健康成年志愿者10人。研究组10人均在伤后72小时内完成BOLD-fMRI检查。两组均采用GE公司制造MR750 3.0T磁共振成像系统，在静息态下采集BOLD-fMRI成像数据。结果：与对照组比较，研究组在边缘叶、扣带回、楔前叶、左侧颞上回、颞中回、右侧额上回等脑区表现为ALFF值升高，临床上出现记忆能力、语言表达、情绪反应等认知功能改变。结论：脑震荡急性期患者认知功能异常，可能与边缘叶、扣带回、右侧前额叶等脑区ALFF值升高相关。 Objective: To investigate the change of amplitude of low-frequency fluctuation (ALFF) in acute phase patients with concussion. Methods: 10 patients with concussion and 10 healthy control subjects were performed at GE MR750 3T by using the methods of blood oxygenation level de-pendent-functional magnetic resonance imaging (BOLD fMRI) and ALFF in this study. Results: Compared with the control subjects, the patients with concussion showed significantly increased ALFF values in limbic lobe, cingulate gyrus, precuneus, left superior temporal gyrus, left middle temporal gyrus and right frontal gyrus. The clinical manifestations of these patients were the changes of cognitive function such as memory, language and emotional responses. Conclusion: The changes of cognitive function on the patients with concussion were associated with the increased ALFF values in the cognitive-related brain areas.