Hemodynamics effects of adrecizumab in sepsis rat

A Blet,M Sadoune,E Polidano,R Merval, C Bernard,JL Samuel,A Mebazaa

Intensive Care Medicine Experimental（2015）

Cited 1|Views25

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Abstract

Sepsis and septic shock still represent major health issues, with persisting high morbidity and mortality rates in critically ill patients. Cardiac dysfunction[1] occurs frequently during severe sepsis. Adrenomedullin (ADM) has been identified as a key mediator in vascular tone regulation[1]. A newly developed anti-ADM antibody Adrecizumab (ADZ) may improve hemodynamic dysfunction during resuscitated murine, cecal ligation and puncture (CLP)-induced septic shock[2].

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Key words

Septic Shock,Severe Sepsis,Mean Arterial Pressure,Hemodynamic Effect,Vascular Dysfunction

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