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SMAP: a streamlined methylation analysis pipeline for bisulfite sequencing

Shengjie Gao,Dan Zou,Likai Mao, Quan Zhou,Wenlong Jia, Yi Huang,Shancen Zhao,Gang Chen,Song Wu, Dongdong, Li,Fei Xia, Huafeng Chen,Maoshan Chen,Torben F Ørntoft,Lars Bolund,Karina D Sørensen

GigaScience（2015）

Cited 13|Views51
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Abstract
DNA methylation has important roles in the regulation of gene expression and cellular specification. Reduced representation bisulfite sequencing (RRBS) has prevailed in methylation studies due to its cost-effectiveness and single-base resolution. The rapid accumulation of RRBS data demands well designed analytical tools.
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Key words
Reduced representation bisulfite sequencing (RRBS),Differentially methylated region (DMR),Allele-specific DNA methylation (ASM)
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