Tumorzellen — Vehikel mit defekten Bremsen

Protein tyrosine phosphatases (PTP) counteract the enzymatic activity of protein tyrosine kinases. Impaired activity of some members of the PTP family has been found in cancer cells of different malignancies. We have characterized defects in the function of a PTP which negatively regulates the receptor tyrosine kinases FLT3 (Fms-like tyrosine kinase 3), and PDGFR (platelet-derived growth factor receptor) in acute myeloid leukaemia and meningioma cells.