Components, Initiation, Elongation, Termination, and Regulation

This article is intended to provide the reader with an overview of eukaryotic protein synthesis, from its component parts, to pathways for initiation, elongation and termination. The article addresses the consequences of global regulation as evidenced via eIF2 and 4E-BP phosphorylation, events that have differential effects on the pattern of protein synthesis. The process of protein synthesis is discussed based upon both cell free studies and studies in either yeast or tissue culture cells.