Исследование влияния полиморфных замен в гене рецептора витамина d на риск развития рака предстательной железы в Западно-Сибирском регионе РФ

In this study we have analyzed the association of the VDR gene polymorphisms (rs2228570 and rs2238135) with prostate cancer in patients residing in the West Siberia. 393 DNA samples of Caucasian men with PC were enrolled in this study. Control group consisted of 384 Caucasian men without a history of cancer. Genotyping was carried out by real-time PCR using competitive TaaMan probes. Our data indicate that SNPs did not show any association with risk of prostate cancer: 0R(C.I.95%)=0,99 (0,81-1,21), p=0,9 for T-allele of rs2228570 and 0R(C.I.95%)=0,93 (0,75-1,16), p=0,5 for the C-allele of rs2238135. Analysis of haplotype rs2228570-rs2238135 in the control and case groups also did not show statistically significant association with risk of prostate cancer. Based on the data obtained, we conclude that genetic polymorphisms in VDR do not increase the risk for prostate cancer.