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白介素-10基因1082G/A多态性与急性冠脉综合征的关联性

Zhi-hong QIAN,Yue NI,Yin-fu LI,Lei-zhong SHI,Jun JIANG,Ling-ling YAN

Chinese Heart Journal（2014）

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Abstract
目的:探讨常州地区汉族人群白介素-10(IL-10)基因1 082G/A多态性与急性冠脉综合征(ACS)的关联性.方法:ACS组471例,对照组197例,采用基因测序技术检测基因型,并调查相关因素和测定血脂.结果:IL-10基因1 082G/A中在ACS组和对照组中均存在GG、AG和AA 3种基因型;与对照组相比,3种基因型分布频率、等位基因分布频率均无统计学差异;调整对多个危险因素行多元Logistic回归分析,示IL-10基因1 082G/A 3种基因型与ACS的发病仍无相关性.结论:IL-10基因1 082G/A多态性与常州地区汉族人群ACS的发病无关联.
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Key words
acute coronary syndrome,interleukin-10,gene polymorphism
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