Therapeutic efficacy evaluation of anthelmintics activity of albendazole and ivermectin drench formulations in donkeys in Darfur, Sudan

The therapeutic efficacies of albendazole and ivermectin drench formulation at the manufacturer's recommended dose were evaluated in a controlled trial in Nyala town, South Darfur State, Sudan The study involved 24 donkeys naturally infected with gastrointestinal nematodes. they were divided into four groups of equal size Albendazole was administered orally once at a close rate of 10 mg/kg body mass, or twice, 14 days apart at dose rate of 10 mg/kg body mass Ivermectin was administered orally as a single dose at 200 mu g/kg body mass Treatment efficacy was based on the mean faecal egg count reduction 14 days post treatment A faecal egg count reduction of 100% was found after treatment with albendazole and ivermectin In addition efficacy percentages of albendazole and ivermectin against immature and adult nematodes were as follows Trichostrongylus axei 67 09% and 100%. Parascar is equorum 100% and 100%. Oxyuris eau, 100% and 100%, Strongylus sp 98 4% and 100%, and small strongyles 100% and 100% Albendazole single and twice and ivermectin with the single dose showed moderate efficacy (33%. 59 08% and 62 71%, respectively) against larvae found in the cranial mesenteric artery aneurisms No adverse reactions were observed in treated donkeys during the experiment period