TRANSCATHETER CLOSURE OF LARGE PATENT DUCTUS ARTERIOSUS WITH SEVERE PULMONARY ARTERIAL HYPERTENSION IN ADULTS: TWO-YEAR FOLLOW-UP RESULTS

Aim To evaluate the immediate and follow-up results of transcatheter closure of large PDAs with severe pulmonary arterial hypertension (PAH) in adults. Method After a complete haemodynamic evaluation differentiating from the reversibility of severe PAH, transcatheter closure of PDA was performed. Patients were followed up clinically and echocardiographically at 24 h, 1 month, 3 months, 6 months, 12 months and 24 months after occlusion. Results 38 patients had successful occlusion, PAP, LVEF and FS significantly decreased immediately after occlusion (92.5±23.1 mm Hg vs 47.2±15.7 mm Hg, p Conclusion Transcatheter closure of large PDA with severe PAH is feasible, effective, and safe in the adults. Significant LV systolic changes may occur after closure of large PDA, and LV function usually recovers within a few months. Further study should be performed.