ADMISSION HYPOGLYCAEMIA AND HYPERGLYCAEMIA ARE ASSOCIATED WITH INCREASED MORTALITY IN OLDER PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Objective The aim was to assess the association between fasting plasma glucose (FPG) levels on admission and mortality in older patients with acute myocardial infarction (AMI), and compare the effects of FPG levels on outcomes in the context of contemporary treatments, including medical therapy, percutaneous coronary intervention and coronary artery bypass grafting. Methods From April 2004 to October 2006, 1854 older (age ≥65 years) AMI patients were enrolled in the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS) consecutively. Patients were categorised into 4 groups: hypoglycemia group (N=443, 23.9%), FPG≤5 mmol/l; euglycemia group (N=812, 43.8%), 5.1 mmol/l≤ FPG≤7 mmol/l (5–7 mmol/l); mild hyperglycemia group (N=308, 16.6%), 7.1 mmol/l≤FPG≤9 mmol/l (7–9 mmol/l); and severe hyperglycemia group (N=291, 15.7%), FPG≥9.1 mmol/l. The primary end point was in-hospital and 3-year all-cause mortality from the day of admission. Results Compared with euglycemia group, hypo- or hyperglycemia groups were all associated with higher in-hospital and 3-year all-cause mortality. There was a U-shaped relationship between admission FPG levels and short- and long-term all-cause mortality. This U-shaped relationship applied equally to subgroups in the context of contemporary treatments. Conclusions In older patients with AMI, increased as well as decreased admission FPG levels could predict higher in-hospital and 3-year mortality. There was a striking U-shaped relationship between admission FPG levels and short- and long-term mortality. An initial admission FPG level of 5–7 mmol/l may be desirable because it was associated with better clinical outcomes.