Certolizumab pegol therapy of rheumatoid arthritis: Overview
DRUG DEVELOPMENT RESEARCH(2011)
Abstract
First-line treatment for moderate to severe rheumatoid arthritis (RA) has been the use of disease-modifying anti-rheumatic drugs (DMARDs), e.g., methotrexate. Because of the cases of failure reported to respond to available treatments, newer RA drugs including tumor necrosis factor (TNF-a) blockers have emerged. Certolizumab pegol (CZP) is a unique polyethylene glycolated (PEG) humanized monoclonal antibody designed specifically to target TNF-a pro-inflammatory cytokine. Given that its properties closely reflect its PEG fragment, CZP has demonstrated a clear efficiency. Pharmacokinetics and pharmacodynamics of CZP are described together with Phase II and III CZP clinical studies focused on CZP efficiency and safety. We also discuss the future of CZP and new clinical studies that might help physicians in their choice of CZP among available TNF-a blockers. Drug Dev Res 72:603614, 2011. (c) 2011 Wiley Periodicals, Inc.
MoreTranslated text
Key words
Certolizumab pegol,TNF-a,inhibitors,rheumatoid arthritis,autoimmune disease
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined