Application of Ozone Therapy in Patients with Knee Osteoarthritis

Osteoarthritis is a common degenerative joint disease. Taking into account the ozone (O3) effects in cellular redox balance and upon biomarkers of inflammation, the aim of this study was to evaluate the action of ozone therapy in oxidative stress parameters in synovial fluid of patients suffering of knee osteoarthritis and their clinical evolution. In 42 patients, O3 was administered rectally and by intra-articular applications. Synovial fluid was extracted for the measurement of parameters associated with oxidative stress. Also, evaluation of the joint capacity, pain, and ultrasound imaging were performed. Combined ozone therapy produced an intra-articular redox balance and a significant reduction of pain.