Genetic screening of oocyte donors and known sperm donors: an ART practice survey

ObjectiveTo examine practice patterns of assisted-reproduction programs regarding required or recommended genetic screening of anonymous and known oocyte donors and known sperm donors.DesignCross-sectional survey.Materials and MethodsA one-page questionnaire was offered to attendees at a 2014 national symposium on third-party reproduction. Descriptive statistics were compiled and analyzed by Fisher’s exact test.ResultsTabled 1ScreeningAnonymous OocyteKnown Spermp-Value*ACOG Recommendations28/46 (61%)17/30 (57%)0.37ACMG Recommendations13/46 (28%)8/30 (27%)0.16Ethnic History25/46 (54%)13/30 (43%)0.026Only per Recipient Request0/46 (0%)8/30 (27%)3-Generation Pedigree18/46 (39%)6/30 (20%)0.020Karyotype13/46 (28%)2/30 (7%)0.026Comprehensive GCS21/46 (46%)7/30 (23%)0.020*McNemar’s test for difference. ACMG=American College of Medical Genetics. Open table in a new tab ConclusionGenetic screening of oocyte donors is obtained universally but inconsistently follows published guidelines. Genetic screening of known gamete donors tends to track that used for anonymous oocyte donors, but use of comprehensive or history-targeted GCS of known sperm donors is less frequent than for anonymous egg donors. ObjectiveTo examine practice patterns of assisted-reproduction programs regarding required or recommended genetic screening of anonymous and known oocyte donors and known sperm donors. To examine practice patterns of assisted-reproduction programs regarding required or recommended genetic screening of anonymous and known oocyte donors and known sperm donors. DesignCross-sectional survey. Cross-sectional survey. Materials and MethodsA one-page questionnaire was offered to attendees at a 2014 national symposium on third-party reproduction. Descriptive statistics were compiled and analyzed by Fisher’s exact test. A one-page questionnaire was offered to attendees at a 2014 national symposium on third-party reproduction. Descriptive statistics were compiled and analyzed by Fisher’s exact test. ResultsTabled 1ScreeningAnonymous OocyteKnown Spermp-Value*ACOG Recommendations28/46 (61%)17/30 (57%)0.37ACMG Recommendations13/46 (28%)8/30 (27%)0.16Ethnic History25/46 (54%)13/30 (43%)0.026Only per Recipient Request0/46 (0%)8/30 (27%)3-Generation Pedigree18/46 (39%)6/30 (20%)0.020Karyotype13/46 (28%)2/30 (7%)0.026Comprehensive GCS21/46 (46%)7/30 (23%)0.020*McNemar’s test for difference. ACMG=American College of Medical Genetics. Open table in a new tab *McNemar’s test for difference. ACMG=American College of Medical Genetics. ConclusionGenetic screening of oocyte donors is obtained universally but inconsistently follows published guidelines. Genetic screening of known gamete donors tends to track that used for anonymous oocyte donors, but use of comprehensive or history-targeted GCS of known sperm donors is less frequent than for anonymous egg donors. Genetic screening of oocyte donors is obtained universally but inconsistently follows published guidelines. Genetic screening of known gamete donors tends to track that used for anonymous oocyte donors, but use of comprehensive or history-targeted GCS of known sperm donors is less frequent than for anonymous egg donors.