Comparison of art clinical outcomes between patients with spinal cord injury and congenital bilateral absence of the vas deference

It was difficult for patients with spinal cord injury (SCI) to get children because of an ejaculation disorder and a spermatogenesis malfunction as well as a functional motility disorder. However, in late years it is not difficult for the SCI patients to get children by the development of the assisted reproduction technology such as ICSI and testicular sperm extraction (TESE). The objective of this study was to compare ART clinical outcomes with testicular sperms between the SCI patients and the congenital bilateral absence of the vas deference (CBAVD) patients. Comparison of ART clinical outcomes between patients with SCI and CBAVD. 105 TESE-ICSI cycles in the SCI group and 87 TESE-ICSI cycles in the CBAVD group between January 1999 and December 2011 were included in this study. The results in the SCI group and the CBAVD group were compared. The average age of husband and wife of both groups did not have the significant difference. The number of the oocyte collection in the SCI group was significantly higher than that in the CBAVD group (12.6±7.0 vs. 8.9±7.2; P<0.01). However, the fertilization rate in the SCI group was significantly lower than that in the CBAVD group (70.7% vs 79.6%; P<0.0001). The cleavage rate in the SCI group was also significantly lower than that in the CBAVD group (92.5% vs 99.2%; P<0.0001). The pregnancy rate and the implantation rate did not have the significant difference between the two groups. However, the delivery rate in the SCI group was significantly lower than that in the CBAVD group (20.2% vs 37.1%; P=0.0179). In this result, the fertilization rate and the delively rate in the SCI group were lower than those in the CBAVD group, despite good ovarian function in the SCI group. As the reason of the result, it is considered that testicular function of the SCI patient maybe decline.