Iodocyclisations reactions of Boc- and Cbz-protected N -allylguanidines

Zainab Al Shuhaib, D H Davies,Mark Dennis,Daniel M Evans,Matthew D Fletcher,Herjan Franken, Paul Hancock,Jackie Hollinshead,Iestyn Jones,Kristina Kahm,Patrick J Murphy,Robert J Nash,David Potter,Richard Rowles

Tetrahedron（2014）

Cited 12|Views36

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Abstract

The cyclisation of mono-protected and bis-protected guanidines 8a–j under standard iodocyclisation conditions (I2/K2CO3) gave the guanidine heterocycles 9–25 via either a direct cyclisation or by a cyclisation/ring-contraction process, which could be controlled by careful selection of conditions.

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Key words

Guanidine,Iodocyclisation,Rearrangement

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