Facile synthesis of C-terminal peptide thioacids under mild conditions from N -sulfanylethylanilide peptides
Tetrahedron(2016)
摘要
A facile procedure has been developed for the synthesis of C-terminal peptide thioacids under mild conditions. A series of N-sulfanylethylanilide peptides prepared using Fmoc-based solid-phase peptide synthesis were successfully converted to the corresponding thioacids via a hydrothiolysis reaction in a phosphate buffer with only trace epimerization of the C-terminal amino acid.
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关键词
C-Terminal peptide thioacids,N-Sulfanylethylanilide peptide,Hydrothiolysis,Phosphate buffer
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