Control of catalysis in globin coupled adenylate cyclase by a globin-B domain

Jayasree Roy,Sumit Sen Santara,Ayan Adhikari,Aditi Mukherjee,Subrata Adak

Archives of Biochemistry and Biophysics（2015）

引用 6|浏览10

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摘要

•HemAC-Lm has two globin domains (globin-A and globin-B).•Heme can only bind at globin-A domain but not at globin-B domain in HemAC-Lm.•In absence of globin-A domain, globin-B domain inhibits AC activity.•Globin-A domain relieves globin-B domain induced inhibition in HemAC-Lm.

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关键词

Leishmania,Heme protein,Mutation,Spectroscopic studies,Adenylate cyclase,Gas sensor proteins

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