An Open-Label Study To Evaluate The Effect Of 5,000 Iu Of Vitamin D3 Softgel On Serum 25-Hydroxyvitamin D Levels Among Healthy Adults

Background: There has been little research performed to determine the most effective vehicle, from a bioavailability perspective, for vitamin D supplementation. It has been observed that further studies are needed to compare the bioavailability from the use of different vehicles (eg, powders, oils, and ethanol). Objective: To assess the effect of a 5,000 IU vitamin D3 lipid-based softgel formulation on serum 25-hydroxyvitamin D levels in healthy male and female subjects already taking a daily 5,000 IU vitamin D3 encapsulated powder formulation for at least 3 months. Methods: After discontinuing their vitamin D3 capsules, 16 qualified participants were dispensed and instructed to take a lipid-based softgel formulation containing 5,000 IU vitamin D3 for 60 days. Assessments of 25-hydroxyvitamin D level were conducted at baseline (prior to vitamin D3 softgel ingestion), Day 30, and Day 60. Results: Fifteen participants completed the study with no serious adverse events reported. 25-hydroxyvitamin D levels in...