Tolerance and Cognitive Function Effects of a Proprietary Spearmint Extract in Men and Women with Self‐Reported Memory Impairment ‐ A Pilot Study (LB402)

This pilot trial assessed the tolerance of a proprietary extract from Mentha spicata L. and its effects on cognition in subjects with self-reported memory impairment. Subjects (N = 11) consumed 900 mg of the extract daily for 30 d. Participants were 73% female and 27% male with a mean age and body mass index of 58.7 y and 27.4 kg/m2. Tolerance was assessed by evaluation of gastrointestinal (GI) tolerability, adverse events, and clinical laboratory tests at baseline and the end of treatment (EOT). Acute cognitive effects were evaluated by comparing pre-dose vs. 0.5 to 4 h post-dose values at baseline and EOT. Subjective cognition was also assessed at the EOT. Consumption of the extract for 30 d did not significantly alter GI symptoms and subjective cognition improved (3.5 vs. 4.0; P = 0.063). No serious adverse events or clinically relevant findings in the safety parameters were observed. Cognitive function task scores suggest improved reasoning (24.7 vs. 33.4 points; P = 0.023), attention/concentration (1...