pH-Dependent structural ensembles of haptoglobin suppress β2-microglobulin amyloidosis: role in lysosomal localization and extracellular protein quality control (752.7)
The FASEB Journal(2014)
摘要
Several diseases involve extracellular deposition of misfolded proteins, which is associated with inflammation and local acidosis. We have investigated the chaperone-like activity of haptoglobin to...
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关键词
haptoglobin,extracellular protein quality control,lysosomal localization
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