Structural characterization of mixed wt/mutant aquaporin‐2 tetramers using dual‐colored fluorescent subunit counting (1133.1)

Yoann Lussier,Hugo McGuire,Abdulah El Tarazi,Pierre Bissonnette,Rikard Blunck,Daniel Bichet

The FASEB Journal（2014）

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摘要

Mutations in Aquaporin-2 (AQP2) induce nephrogenic diabetes insipidus, a water reabsorption defect of the kidney. Using co-immunoprecipitation and functional assays, we have recently shown that (at...

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