Analysis Of Leptin Receptor And Vascular Reactivity Changes In Aorta And Isolated Heart Rat With Low Weight At Birth And With High Hypercaloric Diet/Diabetes Type 2 Model

This work study the expression of leptin ObRb receptor and the functional changes in the vascular reactivity in thoracic and abdominal aorta and isolated heart, obese and control Sprague Dawley rats were study, in one group was induced intrauterine malnutrition (E) due to the 50% food restriction in the pregnant rats and was compare with another group with any food restriction, control (C). The newborns with low weight at birth (BPN) group E had been feed with hypercaloric diet (60% lipids) until 6 months older. Recognize the vascular effect of angiotensin II and phenylephrine in thoracic and abdominal rings and isolated heart rat, and in the other hand we analyze the RNA total expression and RT‐PCR for ObRb receptor. Results Intrauterine malnutrition showed BPN in the group E (p<0.01) compare with group C, and at 6 months older the difference between 2 groups was ±100g for group E with the hypercaloric diet. Group E showed a hyperglycemic (p<0.01), like an increment in the leptin receptor ObRb expression (p<0.01) compared with the group C. On the other hand both groups showed differences in the vascular reactivity and heart responses for angiotnesin II, it's possible that those could be by the changes in the leptin receptor expression in the obese rat.