Anti-Hypernociceptive Property Of The Methanolic Extract Of Stems Of Kielmeyera Rugosa In Mice

The present study examined the anti‐hypernociceptive effect of the methanolic extract of stems of Kielmeyera rugosa (MEKR) in mice. For assess this effect were realized models of mechanic hypernociception induced by carrageenan (CG) and substances which mediate the various reactions involved CG, such as TNF‐α, prostaglandin (PGE 2 ) and dopamine (DA). The mice were pretreated with vehicle (saline + Tween 80 0.2%; p.o.) or MEKR (100, 200 and 400 mg/kg, p.o.). Thirty minutes after the treatments, were injected in region subplantar of the rear right paw: 20 μL of CG (300 μg/paw), PGE 2 (100 ng/paw), DA (30 μg/paw) or TNF‐α (100 pg/paw). The hypernociception was assessed in times of 0.5, 1, 2 and 3 hours after the injection of CG, TNF‐α, PGE 2 and DA, with digital Von Frey. It was observed that MEKR was able to maintain the baseline nociceptive threshold in all tests. The results suggest anti‐hypernociceptive property of MEKR, probably by a mechanism inhibition of production of cytokines, which activate various reactions connected with inflammation, reducing thereby hipernociception. Financial support: FAPITEC/SE, CAPES, CNPq (Brazil).